A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia

Haematologica. 2007 Feb;92(2):260-1. doi: 10.3324/haematol.10753.

Abstract

We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Mutational Analysis*
  • Humans
  • Ikaros Transcription Factor
  • Leukemia / blood*
  • Leukemia / genetics*
  • Lymphocytes / cytology*
  • Mutation*
  • Phosphorylation
  • Protein Structure, Tertiary
  • Trans-Activators / blood*
  • Trans-Activators / chemistry
  • Trans-Activators / genetics*
  • Transcription Factors
  • Zinc Fingers

Substances

  • IKZF3 protein, human
  • Trans-Activators
  • Transcription Factors
  • Ikaros Transcription Factor