Abstract
We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
DNA Mutational Analysis*
-
Humans
-
Ikaros Transcription Factor
-
Leukemia / blood*
-
Leukemia / genetics*
-
Lymphocytes / cytology*
-
Mutation*
-
Phosphorylation
-
Protein Structure, Tertiary
-
Trans-Activators / blood*
-
Trans-Activators / chemistry
-
Trans-Activators / genetics*
-
Transcription Factors
-
Zinc Fingers
Substances
-
IKZF3 protein, human
-
Trans-Activators
-
Transcription Factors
-
Ikaros Transcription Factor