Abstract
We each have nephrotic patients who become steroid dependent and in whom multiple immunosuppressive agents are employed. There is a need to balance possible therapeutic benefits with drug toxicity. This case report describes such a patient, who has suffered from nephrotic syndrome for over 11 years and had become resistant to the usual therapies. He was therefore given a single dose of the anti-CD20 drug rituximab, to which he showed a prompt response, leaving him free of proteinuria for the past 10 months.
MeSH terms
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Antibodies, Monoclonal / therapeutic use*
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Antibodies, Monoclonal, Murine-Derived
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Child, Preschool
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Disease-Free Survival
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Drug Resistance
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Glomerular Mesangium / chemistry
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Glomerular Mesangium / ultrastructure
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Humans
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Immunoenzyme Techniques
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Immunoglobulin A / analysis
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Immunologic Factors / therapeutic use*
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Immunosuppressive Agents / therapeutic use
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Male
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Nephrotic Syndrome / drug therapy*
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Rituximab
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Treatment Outcome
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Immunoglobulin A
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Immunologic Factors
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Immunosuppressive Agents
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Rituximab