Abstract
Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Dose-Response Relationship, Drug
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GB virus C / physiology
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HIV Infections / virology*
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HIV-1 / physiology*
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Humans
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Recombinant Fusion Proteins / pharmacology
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Transfection
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / pharmacology
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Viral Envelope Proteins / physiology*
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Virus Replication / drug effects
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Virus Replication / physiology*
Substances
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Recombinant Fusion Proteins
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Viral Envelope Proteins
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glycoprotein E2, GB virus C