Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York

Clin Infect Dis. 2007 Apr 1;44(7):972-5. doi: 10.1086/512370. Epub 2007 Feb 21.

Abstract

A carbapenem-resistant isolate of Escherichia coli was identified that possessed a 23-kb plasmid encoding Klebsiella pneumoniae carbapenemase type 2 (KPC-2). A subsequent surveillance study involving hospitals in Brooklyn, New York, revealed that, among 1417 E. coli isolates, 7 isolates (from 3 hospitals) possessed bla(KPC-2). E. coli possessing KPC-2 is emerging in our region, and improved methods for detection are urgently needed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / metabolism*
  • Carbapenems / pharmacology
  • Cross Infection / epidemiology
  • Cross Infection / microbiology
  • Disease Outbreaks*
  • Drug Resistance, Bacterial
  • Escherichia coli / classification
  • Escherichia coli / enzymology*
  • Escherichia coli Infections / diagnosis
  • Escherichia coli Infections / epidemiology*
  • Humans
  • Incidence
  • Male
  • Microbial Sensitivity Tests
  • New York City / epidemiology
  • Polymerase Chain Reaction
  • Population Surveillance
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-lactamase KPC-2
  • beta-Lactamases
  • carbapenemase