Vascular endothelial growth factor family of ligands and receptors: review

Zaher K Otrock; Jawad A Makarem; Ali I Shamseddine

doi:10.1016/j.bcmd.2006.12.003

Vascular endothelial growth factor family of ligands and receptors: review

Blood Cells Mol Dis. 2007 May-Jun;38(3):258-68. doi: 10.1016/j.bcmd.2006.12.003. Epub 2007 Mar 6.

Authors

Zaher K Otrock¹, Jawad A Makarem, Ali I Shamseddine

Affiliation

¹ Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut 1107 2802, Lebanon.

PMID: 17344076
DOI: 10.1016/j.bcmd.2006.12.003

Abstract

VEGF signaling often represents a critical rate-limiting step in physiological angiogenesis. The VEGF family comprises seven secreted glycoproteins that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PlGF) and VEGF-F. The VEGF family members bind their cognate receptors. The receptors identified so far are designated VEGFR-1, VEGFR-2, VEGFR-3 and the neuropilins (NP-1 and NP-2). We review in this article the biology of the VEGF ligands and the receptors.

Publication types

Review

MeSH terms

Animals
Humans
Ligands
Neovascularization, Pathologic*
Neovascularization, Physiologic*
Receptors, Vascular Endothelial Growth Factor*
Vascular Endothelial Growth Factors*

Substances

Ligands
Vascular Endothelial Growth Factors
Receptors, Vascular Endothelial Growth Factor