Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates

Richard V Goering; Linda K McDougal; Greg E Fosheim; Kristin K Bonnstetter; Daniel J Wolter; Fred C Tenover

doi:10.1128/JCM.00273-07

Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates

J Clin Microbiol. 2007 Jun;45(6):1981-4. doi: 10.1128/JCM.00273-07. Epub 2007 Apr 4.

Authors

Richard V Goering¹, Linda K McDougal, Greg E Fosheim, Kristin K Bonnstetter, Daniel J Wolter, Fred C Tenover

Affiliation

¹ Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA. rgoeri@creighton.edu

Abstract

We tested 214 Staphylococcus aureus isolates for the arcA locus of the arginine catabolic mobile element (ACME). All USA300 SCCmec IVa isolates, but no isolates containing other SCCmec subtypes, were arcA positive. arcA was also detected in selected methicillin-susceptible USA300 and methicillin-resistant USA100 isolates. DNA sequence analysis confirmed the integration of ACME in orfX.

MeSH terms

Arginine / metabolism*
Base Sequence
Electrophoresis, Gel, Pulsed-Field
Humans
Interspersed Repetitive Sequences / genetics*
Methicillin / pharmacology*
Methicillin Resistance* / genetics
Microbial Sensitivity Tests
Molecular Sequence Data
Staphylococcal Infections / epidemiology*
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics

Substances

Arginine
Methicillin