A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications

Leuk Res. 2008 Jan;32(1):155-7. doi: 10.1016/j.leukres.2007.03.013. Epub 2007 Apr 8.

Abstract

Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Genes, Immunoglobulin*
  • Humans
  • Immunoglobulin D / metabolism*
  • Immunoglobulin Variable Region / genetics*
  • Immunohistochemistry
  • Lymphoma, B-Cell, Marginal Zone
  • Mutation
  • Splenic Neoplasms / genetics*

Substances

  • Immunoglobulin D
  • Immunoglobulin Variable Region