Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase

Virginija Dudutiene; Lina Baranauskiene; Daumantas Matulis

doi:10.1016/j.bmcl.2007.03.100

Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3335-8. doi: 10.1016/j.bmcl.2007.03.100. Epub 2007 Apr 5.

Authors

Virginija Dudutiene¹, Lina Baranauskiene, Daumantas Matulis

Affiliation

¹ Laboratory of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius LT-02241, Lithuania.

PMID: 17442568
DOI: 10.1016/j.bmcl.2007.03.100

Abstract

A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase II (bCAII) bound the inhibitors with observed association constants in the range from 1.1 x 10(6) to 2.6 x 10(7) M(-1).

MeSH terms

Animals
Benzimidazoles / chemical synthesis
Benzimidazoles / pharmacology*
Binding Sites
Calorimetry / methods
Carbonic Anhydrase I / antagonists & inhibitors*
Carbonic Anhydrase II / antagonists & inhibitors*
Carbonic Anhydrase Inhibitors / chemical synthesis
Carbonic Anhydrase Inhibitors / pharmacology*
Cattle
Humans
Structure-Activity Relationship
Sulfonamides / chemical synthesis
Sulfonamides / pharmacology*
Titrimetry / methods

Substances

Benzimidazoles
Carbonic Anhydrase Inhibitors
Sulfonamides
Carbonic Anhydrase I
Carbonic Anhydrase II