Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871

Ellen Graf; Kathrin Schneider; Graeme Nicholson; Markus Ströbele; Amanda L Jones; Michael Goodfellow; Winfried Beil; Roderich D Süssmuth; Hans-Peter Fiedler

doi:10.1038/ja.2007.35

Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871

J Antibiot (Tokyo). 2007 Apr;60(4):277-84. doi: 10.1038/ja.2007.35.

Authors

Ellen Graf¹, Kathrin Schneider, Graeme Nicholson, Markus Ströbele, Amanda L Jones, Michael Goodfellow, Winfried Beil, Roderich D Süssmuth, Hans-Peter Fiedler

Affiliation

¹ Institut für Chemie, Technische Universität Berlin.

PMID: 17456980
DOI: 10.1038/ja.2007.35

Abstract

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Cell Cycle / drug effects
Cell Line, Tumor
Fermentation
Humans
Magnetic Resonance Spectroscopy
Oxazines / chemistry
Oxazines / isolation & purification*
Oxazines / pharmacology
Streptomyces griseus / classification
Streptomyces griseus / metabolism*
Structure-Activity Relationship

Substances

Antibiotics, Antineoplastic
Oxazines
elloxazinone A
elloxazinone B