Abstract
Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Carbamates / chemistry
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Catalysis
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Chemistry, Organic / methods*
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Models, Chemical
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Molecular Conformation
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Molecular Structure
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Quinolines / chemical synthesis*
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Quinolines / chemistry*
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Stereoisomerism
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Time Factors
Substances
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Amino Acids
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Carbamates
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Quinolines
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torcetrapib