Three new taxanes with the 10-alkoxy group from the heartwood of Taxus cuspidata

Biosci Biotechnol Biochem. 2007 Aug;71(8):2087-90. doi: 10.1271/bbb.70210. Epub 2007 Aug 7.

Abstract

Three novel taxanes with the 10-alkoxy group were isolated from heartwood of Taxus cuspidata. The structures were identified as 2alpha,14beta-diacetoxy-10beta-ethoxytaxa-11,4(20)-dien-5alpha-ol (1), 2alpha,14beta-diacetoxy-10beta-methoxytaxa-11,4(20)-dien-5alpha-ol (2), and 2alpha-acetoxy-10beta-ethoxytaxa-11,4(20)-diene-5alpha,14beta-diol (3) on the basis of spectroscopic analysis. These are the first taxanes with an alkoxy moiety on the skeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols
  • Molecular Structure
  • Spectrum Analysis
  • Taxoids / chemistry*
  • Taxoids / isolation & purification
  • Taxus / chemistry*

Substances

  • Alcohols
  • Taxoids
  • alkoxyl radical