The presence of urticaria associated with Blastocystic Hominis infection has been described in very few studies. To the best of our knowledge, no cases of chronic angioedema associated with Blastocystic hominis have been published. The clinical and immunological data of a patient with said association is presented. In the last 5 years, a 21 year old woman suffered episodic spells of angioedema which affected her lips, face and upper limbs accompanied by recurring urticaria. The patient continually used antihistamines and corticoids. Laboratory and immunological tests were normal. Blastocystic hominis in faeces was identified on three occasions. The angioedema and urticaria, as well as the intestinal infection, were successfully treated with paramomycin sulphate. The angiodema and urticaria continue in remission after 24 months of followup care. This case helps to encourage studies to establish an association between the infection by Blastocystis hominis and the presence of chronic angioedema which does not respond to standard treatment, as this condition can seriously affect the quality of life of sufferers.