Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Franco de Conno; Augusto Caraceni; Cinzia Martini; Elio Spoldi; Monica Salvetti; Vittorio Ventafridda

doi:10.1016/0304-3959(91)90225-M

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Pain. 1991 Dec;47(3):337-339. doi: 10.1016/0304-3959(91)90225-M.

Authors

Franco de Conno¹, Augusto Caraceni, Cinzia Martini, Elio Spoldi, Monica Salvetti, Vittorio Ventafridda

Affiliation

¹ Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, 20133 Milan Italy Department of Radiology, National Cancer Institute of Milan, 20133 Milan Italy Palliative Care Unit, USSL 75 / IV, 20143 Milan Italy.

PMID: 1784504
DOI: 10.1016/0304-3959(91)90225-M

Abstract

We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.

Publication types

Case Reports

MeSH terms

Drug Administration Schedule
Humans
Hyperalgesia / chemically induced*
Injections, Spinal
Male
Middle Aged
Morphine / administration & dosage
Morphine / adverse effects*
Myoclonus / chemically induced*

Substances

Morphine