Abstract
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Gastric Acid / metabolism*
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H(+)-K(+)-Exchanging ATPase / metabolism
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Humans
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KCNQ1 Potassium Channel / metabolism
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Parietal Cells, Gastric / cytology
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Parietal Cells, Gastric / metabolism*
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Parietal Cells, Gastric / pathology
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Potassium / metabolism*
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Potassium Channels, Inwardly Rectifying / metabolism
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Potassium Channels, Voltage-Gated / antagonists & inhibitors
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Potassium Channels, Voltage-Gated / metabolism*
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Signal Transduction / physiology
Substances
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KCNQ1 Potassium Channel
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Potassium Channels, Inwardly Rectifying
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Potassium Channels, Voltage-Gated
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H(+)-K(+)-Exchanging ATPase
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Potassium