Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"

Science. 2007 Oct 19;318(5849):393; author reply 393. doi: 10.1126/science.318.5849.393a.

Abstract

Curtis et al. (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a true ventricular extension.

Publication types

  • Comment

MeSH terms

  • Adult
  • Cell Movement
  • Cell Proliferation
  • Cell Shape
  • Humans
  • Lateral Ventricles / cytology*
  • Neural Cell Adhesion Molecule L1 / analysis
  • Neurons / chemistry
  • Neurons / cytology*
  • Neurons / physiology
  • Olfactory Bulb / cytology*
  • Proliferating Cell Nuclear Antigen / analysis
  • Prosencephalon / cytology
  • Sialic Acids / analysis
  • Stem Cells / chemistry
  • Stem Cells / cytology*
  • Stem Cells / physiology

Substances

  • Neural Cell Adhesion Molecule L1
  • Proliferating Cell Nuclear Antigen
  • Sialic Acids
  • polysialyl neural cell adhesion molecule