Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor?

PLoS Med. 2007 Oct;4(10):1620-2. doi: 10.1371/journal.pmed.0040321.

Abstract

The author discusses three new studies inPLoS Medicine that shed light on the mechanisms involved in apoptosis triggered by EGFR kinase inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Line, Tumor
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / physiology*
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / enzymology*
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use

Substances

  • Protein Kinase Inhibitors
  • ErbB Receptors