Abstract
In this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by Sansone et al. implicates IL-6 in the instigation of malignant properties in breast cancer stem cells (see the related article beginning on page 3988). The study by Gao et al. identifies mutant variants of EGFR as inducers of IL-6 in lung adenocarcinomas (see the related article beginning on page 3846). These studies add to our understanding of potential roles for IL-6 in cancer and further motivate investigations of IL-6-targeted chemotherapeutics.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Animals
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Antigens, Neoplasm / biosynthesis
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Antigens, Neoplasm / genetics
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Autocrine Communication / drug effects
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Autocrine Communication / genetics
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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Breast Neoplasms / therapy
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism
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Carbonic Anhydrase IX
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Carbonic Anhydrases / biosynthesis
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Carbonic Anhydrases / genetics
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Carcinoma / genetics
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Carcinoma / metabolism*
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Carcinoma / pathology
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Carcinoma / therapy
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Cell Hypoxia / drug effects
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Cell Hypoxia / genetics
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Cell Line, Tumor
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Cytokine Receptor gp130 / genetics
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Cytokine Receptor gp130 / metabolism
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Enzyme Inhibitors / pharmacology
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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Female
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Gene Expression Regulation, Neoplastic / drug effects
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Gene Expression Regulation, Neoplastic / genetics
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism
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Interleukin-6 / antagonists & inhibitors
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Interleukin-6 / biosynthesis*
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Interleukin-6 / genetics
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Interleukin-6 / metabolism*
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Interleukin-6 / pharmacology
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Janus Kinases / genetics
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Janus Kinases / metabolism
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Lung Neoplasms / genetics
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Lung Neoplasms / metabolism*
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Lung Neoplasms / pathology
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Lung Neoplasms / therapy
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Mammary Glands, Human / metabolism
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Mammary Glands, Human / pathology
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Mice
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Mice, Nude
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Mutation
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Neoplasm Invasiveness
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasm Proteins / pharmacology
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Neoplasm Transplantation
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Phosphorylation / drug effects
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Neoplasm / biosynthesis
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RNA, Neoplasm / genetics
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RNA, Small Interfering / pharmacology
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Receptor, Notch3
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Receptors, Notch / genetics
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Receptors, Notch / metabolism
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STAT3 Transcription Factor / genetics
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STAT3 Transcription Factor / metabolism
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Serrate-Jagged Proteins
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Spheroids, Cellular / metabolism
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Spheroids, Cellular / pathology
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Stem Cells / metabolism
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Stem Cells / pathology
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Transcription, Genetic / drug effects
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Transcription, Genetic / genetics
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Up-Regulation / drug effects
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Up-Regulation / genetics
Substances
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Antigens, Neoplasm
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Calcium-Binding Proteins
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Enzyme Inhibitors
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IL6 protein, human
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IL6ST protein, human
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Intercellular Signaling Peptides and Proteins
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Interleukin-6
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Membrane Proteins
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NOTCH3 protein, human
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Neoplasm Proteins
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RNA, Messenger
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RNA, Neoplasm
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RNA, Small Interfering
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Receptor, Notch3
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Receptors, Notch
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STAT3 Transcription Factor
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STAT3 protein, human
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Serrate-Jagged Proteins
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Cytokine Receptor gp130
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EGFR protein, human
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ErbB Receptors
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Janus Kinases
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CA9 protein, human
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Carbonic Anhydrase IX
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Carbonic Anhydrases