Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation

S Neuburger; G Massenkeil; M Seibold; C Lutz; I Tamm; P le Coutre; B Graf; B Doerken; R Arnold

doi:10.1111/j.1399-3062.2007.00296.x

Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation

Transpl Infect Dis. 2008 Jul;10(4):290-3. doi: 10.1111/j.1399-3062.2007.00296.x. Epub 2008 Jan 14.

Authors

S Neuburger¹, G Massenkeil, M Seibold, C Lutz, I Tamm, P le Coutre, B Graf, B Doerken, R Arnold

Affiliation

¹ Department of Hematology and Oncology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany. stefan.neuburger@charite.de

PMID: 18194367
DOI: 10.1111/j.1399-3062.2007.00296.x

Abstract

Fusarium infections are associated with high mortality after allogeneic stem cell transplantation. We report on successful treatment of a disseminated cutaneous Fusarium proliferatum infection using liposomal amphotericin B and terbinafine. In vitro susceptibility tests of antifungal drugs suggest that terbinafine is a potent additional antifungal drug for disseminated cutaneous fusariosis.

Publication types

Case Reports

MeSH terms

Amphotericin B / therapeutic use*
Antifungal Agents / therapeutic use*
Dermatomycoses / drug therapy*
Dermatomycoses / microbiology
Drug Therapy, Combination
Female
Fusarium / drug effects
Humans
Middle Aged
Naphthalenes / therapeutic use*
Neutropenia / complications
Salvage Therapy
Stem Cell Transplantation / adverse effects*
Terbinafine
Transplantation, Homologous / adverse effects*
Treatment Outcome

Substances

Antifungal Agents
Naphthalenes
liposomal amphotericin B
Amphotericin B
Terbinafine