Insulin, insulin-like growth factors, insulin resistance, and neoplasia

Am J Clin Nutr. 2007 Sep;86(3):s820-2. doi: 10.1093/ajcn/86.3.820S.

Abstract

An accumulating body of epidemiologic and laboratory evidence suggests that insulin and insulin-like growth factors influence both the risk and the prognosis of cancer. In this brief review, I highlight topics covered in my lecture on research directions in this field, including the view that metformin deserves investigation as a potential adjunct in the treatment or prevention of cancer in persons with hyperinsulinemia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Complications
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / blood*
  • Insulin / metabolism
  • Insulin Resistance*
  • Life Style
  • Metformin / therapeutic use
  • Neoplasms / blood
  • Neoplasms / epidemiology*
  • Neoplasms / prevention & control
  • Obesity / complications
  • Prognosis
  • Risk Factors
  • Somatomedins / metabolism*
  • Somatomedins / physiology

Substances

  • Hypoglycemic Agents
  • Insulin
  • Somatomedins
  • Metformin