Pyranose N-glycosyl amines: emerging targets with diverse biological potential

Curr Top Med Chem. 2008;8(2):101-13. doi: 10.2174/156802608783378837.

Abstract

Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.

Publication types

  • Review

MeSH terms

  • Amines / chemical synthesis
  • Amines / chemistry
  • Amines / pharmacology*
  • Biological Factors / chemical synthesis
  • Biological Factors / chemistry
  • Biological Factors / pharmacology*
  • Crystallography, X-Ray
  • Enzymes / drug effects*
  • Glucose / analogs & derivatives
  • Glucose / chemistry
  • Glucose / pharmacology*
  • Models, Molecular
  • Molecular Conformation
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis
  • Triazoles / chemistry
  • Triazoles / pharmacology*

Substances

  • Amines
  • Biological Factors
  • Enzymes
  • Triazoles
  • Glucose