Abstract
The Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1. At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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DNA-Binding Proteins*
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Drosophila / genetics*
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Drosophila Proteins*
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Mice
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Molecular Sequence Data
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Nuclear Proteins / chemistry*
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Oncogene Proteins / chemistry*
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Polycomb Repressive Complex 1
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Proteins / chemistry*
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Proteins / genetics
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Proto-Oncogene Proteins*
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Repressor Proteins*
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Sequence Homology, Nucleic Acid
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Zinc Fingers
Substances
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Bmi1 protein, mouse
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DNA-Binding Proteins
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Drosophila Proteins
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Nuclear Proteins
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Oncogene Proteins
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Proteins
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Proto-Oncogene Proteins
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Repressor Proteins
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Su(z)2 protein, Drosophila
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Psc protein, Drosophila
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Polycomb Repressive Complex 1