Abstract
Thermolysis of isonitriles with carboxylic acids provides, in one step, N-formyl imides (see, for example, 8 + 19 --> 21). The resultant N-formyl group can be converted to N-H, NCH2OH, or NCH3. This chemistry allows for a new route for synthesizing beta-N (asparagine)-linked glycosyl amino acids.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amides / chemical synthesis*
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Asparagine / analogs & derivatives
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Asparagine / chemical synthesis*
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Carboxylic Acids / chemistry*
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Glycopeptides / chemical synthesis*
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Imides / chemistry
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Models, Chemical
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Nitriles / chemistry*
Substances
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Amides
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Carboxylic Acids
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Glycopeptides
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Imides
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Nitriles
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Asparagine