Review of squamous premalignant vulvar lesions

H P van de Nieuwenhof; I A M van der Avoort; J A de Hullu

doi:10.1016/j.critrevonc.2008.02.012

Review of squamous premalignant vulvar lesions

Crit Rev Oncol Hematol. 2008 Nov;68(2):131-56. doi: 10.1016/j.critrevonc.2008.02.012. Epub 2008 Apr 11.

Authors

H P van de Nieuwenhof¹, I A M van der Avoort, J A de Hullu

Affiliation

¹ Department of Obstetrics & Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

PMID: 18406622
DOI: 10.1016/j.critrevonc.2008.02.012

Abstract

Vulvar squamous cell carcinoma (SCC) develops following two different pathways, which have their own premalignant lesions. In the absence of human papilloma virus (HPV), vulvar SCC can develop in a background of lichen sclerosus (LS), differentiated vulvar intraepithelial neoplasia (VIN) or both. The other pathway leading to vulvar SCC is associated with HPV and the HPV-associated premalignancy is usual VIN. In this review we will discuss the history, epidemiology, aetiology, histology, clinical characteristics, treatment options, malignant potential and prevention strategies of the three squamous premalignant vulvar lesions.

Publication types

Review

MeSH terms

Carcinoma in Situ* / etiology
Carcinoma in Situ* / pathology
Carcinoma in Situ* / therapy
Carcinoma, Squamous Cell* / etiology
Carcinoma, Squamous Cell* / pathology
Carcinoma, Squamous Cell* / therapy
Female
Humans
Papillomavirus Infections* / etiology
Papillomavirus Infections* / pathology
Papillomavirus Infections* / therapy
Precancerous Conditions* / etiology
Precancerous Conditions* / pathology
Precancerous Conditions* / therapy
Vulvar Lichen Sclerosus* / etiology
Vulvar Lichen Sclerosus* / pathology
Vulvar Lichen Sclerosus* / therapy
Vulvar Neoplasms* / etiology
Vulvar Neoplasms* / pathology
Vulvar Neoplasms* / therapy