Disease of the parathyroid glands presents most often with hypercalcaemia secondary to excess parathormone (PTH) production. This is due to a solitary functioning parathyroid adenoma. The role of imaging is primarily to localise the functioning adenoma. Disease of the thyroid may present with a neck mass or thyroid dysfunction. This paper focuses on the approach and choice of imaging techniques in the evaluation of hypercalcaemia and thyroid masses.