Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

J Antibiot (Tokyo). 2008 Mar;61(3):158-63. doi: 10.1038/ja.2008.125.

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / chemistry
  • Actinobacteria / classification
  • Actinobacteria / metabolism*
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Bacteria / drug effects
  • Cell Line, Tumor
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Humans
  • Microbial Sensitivity Tests
  • Netropsin / analogs & derivatives*
  • Netropsin / biosynthesis
  • Netropsin / isolation & purification
  • Netropsin / pharmacology
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • proximicin A
  • proximicin B
  • proximicin C
  • Netropsin