An attempted reversal of cocaine-induced analgesia by dexamethasone

Pharmacol Toxicol. 1991 Feb;68(2):93-5. doi: 10.1111/j.1600-0773.1991.tb02042.x.

Abstract

Analgesia produced by systemic cocaine (20 mg/kg intraperitoneally) was not attenuated by dexamethasone (0.25-2.5 mg/kg) in the formalin or tail pinch test in rats. The result suggests that the activation of the corticotropin releasing factor-adrenocorticotropin/beta-endorphin axis does not explain cocaine-induced analgesia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics*
  • Animals
  • Behavior, Animal / drug effects
  • Cocaine / antagonists & inhibitors*
  • Cocaine / pharmacology
  • Dexamethasone / pharmacology*
  • Formaldehyde
  • Male
  • Pain Measurement
  • Rats
  • Rats, Inbred Strains
  • Reaction Time / drug effects

Substances

  • Analgesics
  • Formaldehyde
  • Dexamethasone
  • Cocaine