Abstract
Analgesia produced by systemic cocaine (20 mg/kg intraperitoneally) was not attenuated by dexamethasone (0.25-2.5 mg/kg) in the formalin or tail pinch test in rats. The result suggests that the activation of the corticotropin releasing factor-adrenocorticotropin/beta-endorphin axis does not explain cocaine-induced analgesia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics*
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Animals
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Behavior, Animal / drug effects
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Cocaine / antagonists & inhibitors*
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Cocaine / pharmacology
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Dexamethasone / pharmacology*
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Formaldehyde
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Male
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Pain Measurement
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Rats
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Rats, Inbred Strains
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Reaction Time / drug effects
Substances
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Analgesics
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Formaldehyde
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Dexamethasone
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Cocaine