Low-fluoride dentifrice and the effect of postbrushing rinsing on fluoride availability in saliva

Eur Arch Paediatr Dent. 2008 Jun;9(2):90-3. doi: 10.1007/BF03262616.

Abstract

Aim: Post-brushing water rinsing may reduce the risk of fluoride (F) ingestion from dentifrice, however the decreased salivary F bioavailability may compromise any consequent anticaries benefits. As the use of low-F concentration dentifrices is still a matter of debate, a comparison was made between the salivary F bioavailability after brushing with a conventional F dentifrice followed by a water rinse and after brushing with a low-F dentifrice without post-brushing rinse.

Study design and methods: In a crossover, blind study, F concentration in saliva of 5 adult volunteers was determined after brushing with a low-F dentifrice (500 microg F/g) or with a conventional F concentration dentifrice (1100 microg F/g), followed or not by a 15-mL water rinse.

Results: Salivary F bioavailability was reduced by 2.5 times when a water rinse was used (p<0.05), irrespective of dentifrice concentration, and it was 2 times lower for the low-F dentifrice (p<0.05). The salivary F bioavailability was similar when the low-F dentifrice was used without post-brushing rinse and the conventional F dentifrice was followed by a rinse (p>0.05).

Conclusion: Habits of post-brushing rinse should be taken into account on the recommendation of dentifrice use by young children, considering the risks and benefits balance of F use.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Area Under Curve
  • Biological Availability
  • Cariostatic Agents / administration & dosage*
  • Cariostatic Agents / analysis
  • Cariostatic Agents / pharmacokinetics
  • Cross-Over Studies
  • Dentifrices / administration & dosage
  • Dentifrices / therapeutic use*
  • Fluorides / administration & dosage*
  • Fluorides / analysis
  • Fluorides / pharmacokinetics
  • Humans
  • Ion-Selective Electrodes
  • Mouthwashes / therapeutic use*
  • Saliva / chemistry
  • Saliva / metabolism*
  • Single-Blind Method
  • Sodium Fluoride / administration & dosage
  • Sodium Fluoride / analysis
  • Sodium Fluoride / pharmacokinetics
  • Time Factors
  • Toothbrushing / methods*
  • Water

Substances

  • Cariostatic Agents
  • Dentifrices
  • Mouthwashes
  • Water
  • Sodium Fluoride
  • Fluorides