The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons

J Comput Neurosci. 2009 Apr;26(2):289-301. doi: 10.1007/s10827-008-0111-9. Epub 2008 Sep 11.

Abstract

The response of an oscillator to perturbations is described by its phase-response curve (PRC), which is related to the type of bifurcation leading from rest to tonic spiking. In a recent experimental study, we have shown that the type of PRC in cortical pyramidal neurons can be switched by cholinergic neuromodulation from type II (biphasic) to type I (monophasic). We explored how intrinsic mechanisms affected by acetylcholine influence the PRC using three different types of neuronal models: a theta neuron, single-compartment neurons and a multi-compartment neuron. In all of these models a decrease in the amount of a spike-frequency adaptation current was a necessary and sufficient condition for the shape of the PRC to change from biphasic (type II) to purely positive (type I).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / metabolism*
  • Algorithms
  • Cerebral Cortex / cytology
  • Cerebral Cortex / physiology*
  • Computer Simulation
  • Membrane Potentials
  • Models, Neurological*
  • Neurons / cytology
  • Neurons / physiology*
  • Software
  • Synapses / physiology
  • Synaptic Transmission

Substances

  • Acetylcholine