Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides

Clin Pharmacol Ther. 2008 Nov;84(5):628-32. doi: 10.1038/clpt.2008.174. Epub 2008 Sep 17.
No abstract available

MeSH terms

  • Drug Delivery Systems*
  • Genome, Human / physiology*
  • Humans
  • Oligodeoxyribonucleotides, Antisense / administration & dosage
  • Oligodeoxyribonucleotides, Antisense / immunology
  • Oligodeoxyribonucleotides, Antisense / therapeutic use*
  • RNA, Small Interfering / administration & dosage
  • RNA, Small Interfering / therapeutic use*
  • Technology, Pharmaceutical / methods
  • Technology, Pharmaceutical / trends*

Substances

  • Oligodeoxyribonucleotides, Antisense
  • RNA, Small Interfering