Discrete event simulation applied to pediatric phase I oncology designs

Clin Pharmacol Ther. 2008 Dec;84(6):729-33. doi: 10.1038/clpt.2008.193. Epub 2008 Oct 15.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Child
  • Child, Preschool
  • Clinical Trials, Phase I as Topic*
  • Computer Simulation*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Maximum Tolerated Dose
  • Medical Oncology / organization & administration
  • Models, Statistical
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Patient Selection
  • Pediatrics / organization & administration
  • Research Design
  • Risk Assessment
  • Sensitivity and Specificity