A cytotoxic substance from Sangre de Grado

H Itokawa; Y Ichihara; M Mochizuki; T Enomori; H Morita; O Shirota; M Inamatsu; K Takeya

doi:10.1248/cpb.39.1041

A cytotoxic substance from Sangre de Grado

Chem Pharm Bull (Tokyo). 1991 Apr;39(4):1041-2. doi: 10.1248/cpb.39.1041.

Authors

H Itokawa¹, Y Ichihara, M Mochizuki, T Enomori, H Morita, O Shirota, M Inamatsu, K Takeya

Affiliation

¹ Tokyo College of Pharmacy, Japan.

PMID: 1893488
DOI: 10.1248/cpb.39.1041

Abstract

Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 microgram/ml against KB cells and 0.17 microgram/ml against V-79 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification*
Alkaloids / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Plants, Medicinal / analysis*
Tumor Cells, Cultured / drug effects

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
taspine