Efficient synthesis and biological evaluation of two modafinil analogues

Carmela De Risi; Luca Ferraro; Gian P Pollini; Sergio Tanganelli; Filippo Valente; Augusto C Veronese

doi:10.1016/j.bmc.2008.10.027

Efficient synthesis and biological evaluation of two modafinil analogues

Bioorg Med Chem. 2008 Dec 1;16(23):9904-10. doi: 10.1016/j.bmc.2008.10.027. Epub 2008 Oct 17.

Authors

Carmela De Risi¹, Luca Ferraro, Gian P Pollini, Sergio Tanganelli, Filippo Valente, Augusto C Veronese

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 19, 44100 Ferrara, Italy. drc@unife.it

PMID: 18954992
DOI: 10.1016/j.bmc.2008.10.027

Abstract

Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzhydryl Compounds / chemistry*
Benzhydryl Compounds / metabolism
Central Nervous System Stimulants / chemical synthesis*
Central Nervous System Stimulants / chemistry
Central Nervous System Stimulants / pharmacology*
Data Interpretation, Statistical
Male
Modafinil
Rats
Rats, Sprague-Dawley
Serotonin / chemistry
Serotonin / metabolism
Stereoisomerism

Substances

Benzhydryl Compounds
Central Nervous System Stimulants
Serotonin
Modafinil