Unstable nucleotide repeat minireview series: a molecular biography of unstable repeat disorders

J Biol Chem. 2009 Mar 20;284(12):7405. doi: 10.1074/jbc.R800067200. Epub 2008 Oct 28.

Abstract

Expansion of an unstable nucleotide repeat is a mutational mechanism that is apparently unique to humans and is known to cause a variety of neurological disorders. This collection of minireviews examines several of these unstable repeats, focusing on those where there is considerable molecular information on how the mutation alters function.

Publication types

  • Introductory Journal Article

MeSH terms

  • Animals
  • Genomic Instability / genetics
  • Heredodegenerative Disorders, Nervous System / genetics*
  • Humans
  • Repetitive Sequences, Nucleic Acid / genetics*