Abstract
We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.
MeSH terms
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Anticoagulants / therapeutic use
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Blood Coagulation Factors / therapeutic use
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Dalteparin / therapeutic use
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Doping in Sports*
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Enoxaparin / therapeutic use
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Hematoma, Subdural / etiology
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Humans
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Male
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Methandrostenolone / adverse effects*
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Pleural Effusion / etiology
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Protein C Deficiency / complications*
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Protein C Deficiency / genetics
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Pulmonary Embolism / etiology*
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Substance-Related Disorders*
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Thrombophilia / chemically induced
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Thrombophilia / genetics
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Thrombophlebitis / drug therapy
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Thrombophlebitis / etiology
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Thrombophlebitis / surgery
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Vena Cava Filters
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Vitamin K / therapeutic use
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Young Adult
Substances
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Anticoagulants
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Blood Coagulation Factors
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Enoxaparin
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Vitamin K
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prothrombin complex concentrates
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Methandrostenolone
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Dalteparin