Abstract
The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.
MeSH terms
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Animals
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Cell Nucleus / ultrastructure
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Child
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Diagnosis, Differential
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Eosinophils / pathology
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Female
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Fetal Death / genetics
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Genes, Dominant
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History, 20th Century
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Humans
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Infections / blood
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Lamin B Receptor
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Leukemia, Myeloid / blood
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Leukemia, Myeloid / diagnosis
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Myelodysplastic Syndromes / blood
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Myelodysplastic Syndromes / diagnosis
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Netherlands
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Neutrophils / pathology*
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Pedigree
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Pelger-Huet Anomaly* / blood
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Pelger-Huet Anomaly* / diagnosis
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Pelger-Huet Anomaly* / genetics
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Pelger-Huet Anomaly* / history
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Receptors, Cytoplasmic and Nuclear / deficiency
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Receptors, Cytoplasmic and Nuclear / genetics
Substances
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Receptors, Cytoplasmic and Nuclear