Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates

Org Biomol Chem. 2008 Dec 21;6(24):4494-7. doi: 10.1039/b815963g. Epub 2008 Oct 17.

Abstract

A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiparasitic Agents / chemistry*
  • Antiparasitic Agents / metabolism
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Catalysis
  • Drug Discovery
  • Humans
  • Metalloporphyrins / chemistry*
  • Metalloporphyrins / metabolism
  • Oxidation-Reduction
  • Quinolines / chemistry*
  • Quinolines / metabolism

Substances

  • Antiparasitic Agents
  • Metalloporphyrins
  • Quinolines
  • quinoline