Abstract
Tremor caused by beta-adrenostimulating drugs is known to be mediated by beta-receptors in skeletal muscles. In this study it was shown that tremor caused by terbutaline could be blocked by propranolol, a drug with both beta1- and beta2-blocking properties, but not by metoprolol, a beta1-selective antagonist. It is concluded that tremor caused by sympathomimetics in man is mainly mediated by beta2-receptors.
MeSH terms
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Blood Pressure / drug effects
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Heart Rate / drug effects
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Humans
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Informed Consent
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Metoprolol / pharmacology
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Propranolol / pharmacology
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Receptors, Adrenergic / physiology*
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Receptors, Adrenergic, beta / physiology*
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Sympathomimetics / pharmacology*
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Terbutaline / antagonists & inhibitors
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Terbutaline / pharmacology
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Tremor / chemically induced*
Substances
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Receptors, Adrenergic
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Receptors, Adrenergic, beta
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Sympathomimetics
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Propranolol
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Metoprolol
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Terbutaline