SLAM receptors and SAP influence lymphocyte interactions, development and function

Nat Rev Immunol. 2009 Jan;9(1):39-46. doi: 10.1038/nri2456.

Abstract

Mutations that affect the adaptor molecule SLAM-associated protein (SAP) underlie the primary immunodeficiency disease X-linked lymphoproliferative syndrome. SAP is required for mediating signals from members of the signalling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors. Recent data have highlighted a role for SAP in the development of innate-like T-cell lineages, including natural killer T cells, and in the regulation of the interactions between B cells and T cells that are required for germinal-centre formation and long-term humoral immunity. These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • CD4-Positive T-Lymphocytes / immunology
  • Cell Adhesion
  • Cell Differentiation
  • Dendritic Cells / immunology
  • Germinal Center / pathology
  • Immunologic Memory
  • Intracellular Signaling Peptides and Proteins / deficiency
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Lymphocyte Activation
  • Lymphocyte Subsets / immunology*
  • Lymphocyte Subsets / metabolism
  • Lymphoproliferative Disorders / genetics
  • Lymphoproliferative Disorders / immunology
  • Mice
  • Multigene Family
  • Natural Killer T-Cells / cytology
  • Natural Killer T-Cells / immunology
  • Plasma Cells / immunology
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Signaling Lymphocytic Activation Molecule Family Member 1

Substances

  • Antigens, CD
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Cell Surface
  • SH2D1A protein, human
  • Sh2d1a protein, mouse
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Signaling Lymphocytic Activation Molecule Family Member 1