Abstract
We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcysteine / pharmacology
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Amphotericin B / pharmacology
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Animals
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Anti-Bacterial Agents / pharmacology*
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Coated Materials, Biocompatible
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Disease Models, Animal*
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Equipment Contamination / prevention & control*
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Gentamicins / pharmacology
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Heart-Assist Devices / microbiology*
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Humans
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Prosthesis-Related Infections / microbiology
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Prosthesis-Related Infections / prevention & control
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Rabbits
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / prevention & control
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development*
Substances
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Anti-Bacterial Agents
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Coated Materials, Biocompatible
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Gentamicins
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Amphotericin B
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Acetylcysteine