Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Infect Control Hosp Epidemiol. 2009 Feb;30(2):190-2. doi: 10.1086/593205.

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / pharmacology
  • Amphotericin B / pharmacology
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Coated Materials, Biocompatible
  • Disease Models, Animal*
  • Equipment Contamination / prevention & control*
  • Gentamicins / pharmacology
  • Heart-Assist Devices / microbiology*
  • Humans
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / prevention & control
  • Rabbits
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / growth & development*

Substances

  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Gentamicins
  • Amphotericin B
  • Acetylcysteine