Abstract
Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / therapeutic use
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Catalysis
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Ethers / chemistry
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Humans
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Influenza, Human / drug therapy*
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Oseltamivir / analogs & derivatives
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Oseltamivir / chemical synthesis*
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Oseltamivir / therapeutic use
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Proline / analogs & derivatives
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Proline / chemistry
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Stereoisomerism
Substances
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Antiviral Agents
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Ethers
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diphenylprolinol silyl ether
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Oseltamivir
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Proline