Instantaneous deprotection of tosylamides and esters with SmI(2)/amine/water

Tobias Ankner; Göran Hilmersson

doi:10.1021/ol802243d

Instantaneous deprotection of tosylamides and esters with SmI(2)/amine/water

Org Lett. 2009 Feb 5;11(3):503-6. doi: 10.1021/ol802243d.

Authors

Tobias Ankner¹, Göran Hilmersson

Affiliation

¹ Department of Chemistry, University of Gothenburg, Göteborg, Sweden.

PMID: 19123840
DOI: 10.1021/ol802243d

Abstract

SmI(2)/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.