Abstract
p53, sometimes referred to as the "guardian of the genome," helps regulate cell-cycle arrest, DNA-damage repair, apoptosis, and senescence. Adding to this list, in this issue of Cell Stem Cell, Liu et al. (2009) show that p53 also plays a role in regulating hematopoietic stem cell quiescence.
MeSH terms
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Animals
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Cell Proliferation
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Cyclin-Dependent Kinase Inhibitor p21 / metabolism
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DNA-Binding Proteins / deficiency
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DNA-Binding Proteins / metabolism
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / metabolism
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Mice
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Models, Biological
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Nerve Tissue Proteins / metabolism
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Nuclear Proteins / metabolism
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Transcription Factors / deficiency
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Transcription Factors / metabolism
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Cyclin-Dependent Kinase Inhibitor p21
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DNA-Binding Proteins
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Elf4 protein, mouse
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Gfi1 protein, mouse
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Nerve Tissue Proteins
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Nuclear Proteins
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Transcription Factors
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Tumor Suppressor Protein p53
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necdin