Hematopoietic stem cell quiescence: yet another role for p53

Cell Stem Cell. 2009 Jan 9;4(1):7-8. doi: 10.1016/j.stem.2008.12.007.

Abstract

p53, sometimes referred to as the "guardian of the genome," helps regulate cell-cycle arrest, DNA-damage repair, apoptosis, and senescence. Adding to this list, in this issue of Cell Stem Cell, Liu et al. (2009) show that p53 also plays a role in regulating hematopoietic stem cell quiescence.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Proliferation
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / metabolism
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism
  • Mice
  • Models, Biological
  • Nerve Tissue Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Transcription Factors / deficiency
  • Transcription Factors / metabolism
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA-Binding Proteins
  • Elf4 protein, mouse
  • Gfi1 protein, mouse
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • necdin