New susceptibility locus for coronary artery disease on chromosome 3q22.3

Nat Genet. 2009 Mar;41(3):280-2. doi: 10.1038/ng.307. Epub 2009 Feb 8.

Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chromosomes, Human, Pair 3*
  • Coronary Artery Disease / genetics*
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Germany
  • Hepatocyte Nuclear Factor 1-alpha / genetics
  • Humans
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • ras Proteins / genetics

Substances

  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • MRAS protein, human
  • ras Proteins