Abstract
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Addictive / genetics
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Behavior, Addictive / metabolism*
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Behavior, Addictive / psychology
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Cocaine / administration & dosage*
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Cocaine / antagonists & inhibitors
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Cocaine-Related Disorders / genetics
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Cocaine-Related Disorders / metabolism
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Cocaine-Related Disorders / psychology
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Dopamine / metabolism
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Dopamine / physiology*
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Mice
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Mice, Transgenic
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Neurons / metabolism
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Neurons / physiology*
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Receptors, Dopamine D1 / antagonists & inhibitors
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Receptors, Dopamine D1 / metabolism
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Receptors, Glucocorticoid / antagonists & inhibitors
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Receptors, Glucocorticoid / biosynthesis
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Receptors, Glucocorticoid / genetics
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Receptors, Glucocorticoid / physiology*
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Self Administration
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Stress, Psychological / genetics
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Stress, Psychological / metabolism*
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Stress, Psychological / psychology
Substances
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NR3C1 protein, human
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Receptors, Dopamine D1
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Receptors, Glucocorticoid
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Cocaine
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Dopamine