Abstract
A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Benzofurans / chemical synthesis*
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Benzofurans / chemistry
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Molecular Structure
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Stereoisomerism
Substances
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Antineoplastic Agents
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Benzofurans
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Biological Products
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Coumarins
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psoralidin