Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome

Eur J Pediatr. 2010 Jan;169(1):35-7. doi: 10.1007/s00431-009-0973-5. Epub 2009 Mar 24.

Abstract

A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient's hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Bacterial / analysis
  • Bronchoalveolar Lavage Fluid / microbiology
  • DNA, Bacterial / analysis
  • Diagnosis, Differential
  • Humans
  • Immunoglobulin E / blood*
  • Infant
  • Job Syndrome / blood
  • Job Syndrome / complications*
  • Job Syndrome / immunology
  • Male
  • Pneumocystis carinii / genetics
  • Pneumocystis carinii / immunology
  • Pneumocystis carinii / isolation & purification*
  • Pneumonia, Pneumocystis / diagnosis
  • Pneumonia, Pneumocystis / etiology*
  • Pneumonia, Pneumocystis / microbiology
  • Radiography, Thoracic
  • T-Lymphocytes, Regulatory / immunology

Substances

  • Antibodies, Bacterial
  • DNA, Bacterial
  • Immunoglobulin E