Abstract
Experiments of mice and rats showed the ability of afobazole (1, 10, and 100 mg/kg, p.o.) upon single, 5-day combined, and 5-day preliminary administration to prevent or significantly decrease the clastogenic effects of the prooxidant agent dioxidine (100 and 300 mg/kg, i.p.) and the clastogenic and teratogenic effects of the alkylating agent cyclophosphamide (20 mg/kg, i.p.).
MeSH terms
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Animals
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Anti-Anxiety Agents / administration & dosage
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Anti-Anxiety Agents / pharmacology*
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Antimutagenic Agents / administration & dosage
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Antimutagenic Agents / pharmacology*
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Benzimidazoles / administration & dosage
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Benzimidazoles / pharmacology*
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Cyclophosphamide / toxicity
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Drug Interactions
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Female
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Morpholines / administration & dosage
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Morpholines / pharmacology*
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Mutagens / toxicity
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Quinoxalines / toxicity
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Rats
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Teratogens / toxicity
Substances
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2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole
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Anti-Anxiety Agents
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Antimutagenic Agents
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Benzimidazoles
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Morpholines
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Mutagens
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Quinoxalines
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Teratogens
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dioxidine
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Cyclophosphamide