Abstract
To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.
MeSH terms
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14-3-3 Proteins / metabolism
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Anaphase-Promoting Complex-Cyclosome
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Animals
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Humans
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Mice
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Models, Biological
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Phosphorylation
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Phosphoserine / metabolism
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Proto-Oncogene Proteins c-akt / chemistry
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Proto-Oncogene Proteins c-akt / metabolism*
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S-Phase Kinase-Associated Proteins / chemistry
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S-Phase Kinase-Associated Proteins / genetics
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S-Phase Kinase-Associated Proteins / metabolism*
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SKP Cullin F-Box Protein Ligases / metabolism
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Ubiquitin-Protein Ligase Complexes / metabolism
Substances
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14-3-3 Proteins
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S-Phase Kinase-Associated Proteins
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Phosphoserine
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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SKP Cullin F-Box Protein Ligases
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Proto-Oncogene Proteins c-akt