Abstract
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae may appear susceptible to imipenem or meropenem by routine susceptibility testing. We report a series of patients with infections caused by K. pneumoniae isolates, which yielded imipenem-susceptible results but were subsequently KPC-positive by polymerase chain reaction. When these infections were treated with imipenem or meropenem, frequent clinical and microbiologic failures were observed.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics
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Female
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Genes, Bacterial
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Humans
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Imipenem / therapeutic use*
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Infant
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / isolation & purification
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Male
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Meropenem
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Middle Aged
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Polymerase Chain Reaction
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Thienamycins / therapeutic use*
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Treatment Failure
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Treatment Outcome
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Young Adult
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Thienamycins
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Imipenem
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beta-Lactamases
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carbapenemase
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Meropenem