Abstract
An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antimetabolites, Antineoplastic / chemical synthesis
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Antimetabolites, Antineoplastic / chemistry*
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Antimetabolites, Antineoplastic / metabolism
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Antimetabolites, Antineoplastic / pharmacology*
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Cell Line, Tumor
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Cell Survival
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Drug Carriers / chemical synthesis*
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Drug Carriers / chemistry
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Drug Carriers / metabolism
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Drug Carriers / pharmacology*
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Fluorouracil / chemical synthesis
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Fluorouracil / chemistry*
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Fluorouracil / metabolism
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Fluorouracil / pharmacology*
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Gold / chemistry*
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Humans
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Metal Nanoparticles / chemistry*
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Photochemistry
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Radiation
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Surface Properties
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Ultraviolet Rays
Substances
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Antimetabolites, Antineoplastic
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Drug Carriers
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Gold
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Fluorouracil